Cxxxvii. Studies in Purine Metabolism
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منابع مشابه
The purine metabolism of Escherichia coli.
Although many tracer studies on the purine metabolism of higher organisms have been reported, there are only preliminary data (1, 2) on the purine metabolism of Escherichiu coli, strain B, the host of the “T series” of bacteriophages. The work presented in this paper was undertaken concomitantly with an investigation of the purine metabolism of the virusinfected cell (3). The study of the purin...
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Studies of human purine metabolism began some 200 years ago with Scheele's identification of uric acid as a constituent of a renal calculus' and Wollaston's demonstration of urate in a tophus from his own ear.2 Just as these were among the earliest experiments in the new science of biochemistry, so Garrod's (1854)3 thread test must rank as the first assay in what we now call the discipline of c...
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The enzymatic reactions responsible for the interconversion of purine nucleotides and for the biosynthesis of the imidazole ring of histidine in bacteria have been described previously (4-7). This study of the isolated enzymes not only revealed the chemical nature of the reactions but also suggested mechanisms for their regulation. The study of purine metabolism described in the present paper w...
متن کاملPurine and pyrimidine nucleotide synthesis and metabolism.
1. Abstract 2. Introduction 3. Purine and pyrimidine metabolism during somatic embryogenesis 3.1. Maintenance of embryogenic tissue 3.1.1. Purine metabolism during maintenance of embryogenic tissue 3.1.2. Pyrimidine metabolism during maintenance of embryogenic tissue 3.2. Development of somatic embryos 3.2.1. Purine metabolism during development of somatic embryos 3.2.2. Pyrimidine metabolism d...
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BACKGROUND The diagnosis of inborn errors of purine and pyrimidine metabolism is often difficult. We examined the potential of 1H-NMR as a tool in evaluation of patients with these disorders. METHODS We performed 1H-NMR spectroscopy on 500 and 600 MHz instruments with a standardized sample volume of 500 microL. We studied body fluids from 25 patients with nine inborn errors of purine and pyri...
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